针对表达严重急性呼吸综合征冠状病毒（SARS-CoV）核蛋白的重组复制缺陷型腺病毒，开展SARS-CoV特异性免疫反应的小鼠研究。
Mouse studies of SARS coronavirus-specific immune responses to recombinant replication-defective adenovirus expressing SARS coronavirus N protein.
作者信息
Sin F W Y, Cheng S C S, Chan K T, Meng L, Yu J, Xie Y
机构信息
Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.
出版信息
Hong Kong Med J. 2009 Feb;15 Suppl 2:33-6.
PMID:19258632
Abstract
- A recombinant adenovirus encoding SARS coronavirus(SARS-CoV) nucleocapsid protein (rAd-N) was constructed. 2. The ability of the rAd-N to induce anti-SARS-CoV N antibody production and cellular immune responses was evaluated in an HLA-A2.1/Kb transgenic mouse model.
摘要
- 构建了一种编码严重急性呼吸综合征冠状病毒（SARS-CoV）核衣壳蛋白的重组腺病毒（rAd-N）。2. 在HLA-A2.1/Kb转基因小鼠模型中评估了rAd-N诱导抗SARS-CoV N抗体产生和细胞免疫反应的能力。
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