Richardson Randal C, Weiss Michael D
Division of Pediatric Neurology, Department of Pediatrics, University of Washington Medical Center and Children's Hospital and Regional Medical Center, Seattle, WA, USA.
J Clin Neuromuscul Dis. 2009 Mar;10(3):122-5. doi: 10.1097/CND.0b013e318190313f.
Hypoglossal neuropathy with associated myokymia as a delayed effect of radiation is a rare occurrence, presumably due to the relative resistance of cranial nerves to injury from irradiation. The authors describe the first case of myokymia of the unilateral tongue with myokymic discharges on needle electromyography after hypofractionated radiation therapy for an extracranial melanoma of the neck. The earlier onset of myokymia than previous cases may represent more direct radiation exposure due to radiation site or the higher radiation dosage administered for treatment of melanomas.
舌下神经病变伴肌束震颤作为放疗的迟发效应较为罕见，可能是由于颅神经对辐射损伤相对具有抗性。作者描述了首例因颈部颅外黑色素瘤接受低分割放疗后出现单侧舌肌束震颤且针极肌电图显示肌束震颤放电的病例。与之前病例相比，该例肌束震颤更早出现，这可能是由于放疗部位导致辐射更直接，或是治疗黑色素瘤时给予的辐射剂量更高。
