Wang V, Liao K K, Ju T H, Lin K P, Wang S J, Wu Z A
Neurological Institute, Veterans General Hospital-Taipei, Taiwan, R.O.C.
Zhonghua Yi Xue Za Zhi (Taipei). 1993 Dec;52(6):413-5.
A 51-year-old man has suffered from progressive dysarthria since 1989. He himself noted slight weakness and tightness of the tongue, so that he was unable to perform motor tasks in a normal fashion. He was diagnosed as having nasopharyngeal carcinoma and had irradiation 70 Gy in 32 divided doses in 1979. Neurological examination revealed left-sided tongue atrophy and myokymia sparing of facial muscles involvement. Electrical discharges of myokymia and neuromyotonia were observed in the tongue muscles, suggesting hypoglossal nerve lesion with hyperexcitability of the axon membrance. Computed tomogram of brain did not show any evidence of recurrence of tumor; indicating that irradiation was the pathologic basis. Our report revealed that myokymia and neuromyotonia of the tongue was an unusual complication of irradiation.
一名51岁男性自1989年以来一直患有进行性构音障碍。他自己注意到舌头有轻微无力和紧绷感，以至于无法正常完成运动任务。他于1979年被诊断为鼻咽癌，并接受了70 Gy的放疗，分32次给予。神经系统检查发现左侧舌肌萎缩和肌纤维颤搐，面部肌肉未受累。在舌肌中观察到肌纤维颤搐和神经性肌强直的放电，提示舌下神经病变伴轴突膜兴奋性增高。脑部计算机断层扫描未显示肿瘤复发的任何迹象；表明放疗是病理基础。我们的报告显示，舌肌纤维颤搐和神经性肌强直是放疗的一种不寻常并发症。
