Ellis C N, Burnette J J, Sedlak R, Dyas C, Blakemore W S
Department of Surgical Education, Baptist Medical Center, Birmingham, Alabama 35213.
Surg Gynecol Obstet. 1991 Oct;173(4):329-42.
Analysis of the DNA of tumors using flow cytometry is a technologic method that can be used to investigate the biologic nature of tumors. While not conclusive, results suggest that this biologic information may be useful in identifying patients with malignant disease who have a worse prognosis. The differentiation of patients with aneuploid tumors into those with hypoploid tumors and those whose tumors are hyperploid may be a further refinement of the technique. Also, a combination of this biologic criteria may allow a more accurate selection of patients than either method alone. Further investigative work needs to be done to fully evaluate the clinical usefulness of flow cytometric DNA analysis and answer these and other questions.
使用流式细胞术分析肿瘤DNA是一种可用于研究肿瘤生物学特性的技术方法。虽然结果并非决定性的，但表明这种生物学信息可能有助于识别预后较差的恶性疾病患者。将非整倍体肿瘤患者区分为亚二倍体肿瘤患者和超二倍体肿瘤患者可能是该技术的进一步细化。此外，结合这种生物学标准可能比单独使用任何一种方法能更准确地选择患者。需要开展进一步的研究工作，以全面评估流式细胞术DNA分析的临床实用性，并回答这些及其他问题。
