Raber M N
Division of Medicine, MD Anderson Hospital and Tumor Institute.
Oncology (Williston Park). 1988 Mar;2(3):35-43, 47.
By providing multiple analyses on single cells, flow cytometry allows the description of cellular heterogeneity, establishing the biologic counterpart of clinical heterogeneity common to most tumors. Analysis of DNA content, a reflection of cell ploidy, is useful in establishing the prognosis of many solid tumors, while analysis of other markers has been crucial in increasing our knowledge of lymphoid differentiation, classifying hematologic malignancies, and detecting minimal residual disease.
通过对单细胞进行多种分析，流式细胞术能够描述细胞异质性，确立大多数肿瘤常见的临床异质性的生物学对应物。DNA含量分析反映了细胞倍性，有助于确定许多实体瘤的预后，而其他标志物的分析对于增进我们对淋巴细胞分化的了解、对血液系统恶性肿瘤进行分类以及检测微小残留病至关重要。
