Kuner R, Hoffmann H, Sültmann H
Molekulare Genomanalyse, Deutsches Krebsforschungszentrum, Heidelberg.
Dtsch Med Wochenschr. 2009 Mar;134(11):519-21. doi: 10.1055/s-0029-1208079. Epub 2009 Mar 3.
The microarray technology allows simultaneous analysis of the global gene expression in cells and tissues. In tumor diseases, important transcriptional changes of genes have been unravelled by this method. The resulted gene expression profiles can be used for the prediction of diagnosis, prognosis or therapeutic outcome, as well as for the identification of novel drug targets. Our review depicts state-of-the-art, limitations, translational applications and future directions concerning microarray analyses in lung cancer.
微阵列技术可同时分析细胞和组织中的整体基因表达。在肿瘤疾病中，通过这种方法已揭示了基因重要的转录变化。所得到的基因表达谱可用于预测诊断、预后或治疗结果，以及用于鉴定新的药物靶点。我们的综述描述了肺癌微阵列分析的最新技术水平、局限性、转化应用和未来方向。
