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胃网膜游离皮瓣修复环状咽缺损后的发病率及功能转归

Morbidity and functional outcomes following gastro-omental free flap reconstruction of circumferential pharyngeal defects.

作者信息

Patel Rajan S, Makitie Antti A, Goldstein David P, Gullane Patrick J, Brown Dale, Irish Jonathan, Gilbert Ralph W

机构信息

Department of Otolaryngology, Head and Neck Surgery, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.

出版信息

Head Neck. 2009 May;31(5):655-63. doi: 10.1002/hed.21016.

Abstract

BACKGROUND

In patients with extensive soft tissue fibrosis requiring circumferential pharyngeal reconstruction following definitive radiotherapy and/or chemotherapy, we take advantage of abundant omental progenitor factors in the tubed gastro-omental free flap. This study reviews our experience with this flap.

METHODS

Review of 11 patients (median follow-up, 2.8 years) undergoing total pharyngolaryngectomy following organ preservation protocols for recurrent squamous cell carcinoma (n = 9) and stricture (n = 2).

RESULTS

Operative morbidity and mortality rates were 54% and 9%, respectively. One patient died following carotid rupture. Complications included: chyle leak (18%), pharyngocutaneous fistula (9%), and late stricture (27%). Ten patients (91%) achieved oral diet, and all 7 patients (100%) considered suitable for tracheoesophageal speech rehabilitation achieved functional speech. Seven patients remain alive without disease at a median of 41 months following surgery.

CONCLUSIONS

The gastro-omental flap provides a viable option in high-risk patients undergoing circumferential pharyngeal reconstruction.

摘要

背景

对于在接受根治性放疗和/或化疗后需要进行环状咽重建的广泛软组织纤维化患者,我们利用带蒂胃网膜游离皮瓣中丰富的网膜祖细胞因子。本研究回顾了我们使用该皮瓣的经验。

方法

回顾11例患者(中位随访时间为2.8年),这些患者因复发性鳞状细胞癌(n = 9)和狭窄(n = 2)按照器官保留方案接受了全喉咽切除术。

结果

手术发病率和死亡率分别为54%和9%。1例患者因颈动脉破裂死亡。并发症包括:乳糜漏(18%)、咽皮肤瘘(9%)和晚期狭窄(27%)。10例患者(91%)能够经口进食,所有7例被认为适合进行气管食管语音康复的患者(100%)都实现了功能性语音。7例患者在术后中位41个月时无疾病存活。

结论

胃网膜皮瓣为接受环状咽重建的高危患者提供了一种可行的选择。

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