Cheepsattayakorn Attapon, Cheepsattayakorn Ruangrong
10th Zonal Tuberculosis and Chest Disease Center, 10th Office of Disease Prevention and Control, Department of Disease Control, Ministry of Public Health, Thailand.
J Med Assoc Thai. 2009 Jan;92(1):136-41.
There is substantial evidence from studies on racial variation in susceptibility to tuberculosis (TB) that human genetic variation is an important determinant of the outcome of infection with Mycobacterium tuberculosis (M tb). In only a minority of cases is there an obvious identifiable risk factor such as human immunodeficiency virus (HIV) infection, advanced age, diabetes, corticosteroid usage or alcohol abuse. In the remainder, a complex interaction of genetic and environmental factors causes the development of clinical TB. Assessment of the contribution of genetics of host resistance to human TB is a long-standing challenge of human genetics research. Several studies demonstrated the association of various human leukocyte antigens (HLA) with disease susceptibility in different ethnic populations. There are likely to be many more TB-susceptibility genes to be identified.
关于结核病（TB）易感性种族差异的研究有大量证据表明，人类基因变异是结核分枝杆菌（M tb）感染结局的重要决定因素。只有少数病例存在明显可识别的风险因素，如人类免疫缺陷病毒（HIV）感染、高龄、糖尿病、使用皮质类固醇或酗酒。在其余病例中，遗传和环境因素的复杂相互作用导致临床结核病的发生。评估宿主抗性基因对人类结核病的作用是人类遗传学研究长期面临的挑战。多项研究表明，不同种族人群中各种人类白细胞抗原（HLA）与疾病易感性相关。可能还有更多的结核病易感基因有待发现。
