人类NRAMP1基因变体与摩洛哥人群对结核病的易感性
Variants of the human NRAMP1 gene and susceptibility to tuberculosis in Morocco.
作者信息
El Baghdadi J, Remus N, Benslimane A, El Annaz H, Chentoufi M, Abel L, Schurr E
机构信息
Service de Génétique Microbienne, Institut Pasteur du Maroc, Casablanca, Maroc.
出版信息
Int J Tuberc Lung Dis. 2003 Jun;7(6):599-602.
It has been well established that the host genetic background is an important modulator of tuberculosis susceptibility. The NRAMP1 (alias SLC11A1) gene has been associated with tuberculosis susceptibility in several ethnic groups. Here we studied the association and linkage of NRAMP1 with tuberculosis in 116 nuclear families, comprising 211 affected offspring, from Casablanca, Morocco. All enrolled tuberculosis cases were culture-positive. No evidence was found of linkage or association of NRAMP1 with tuberculosis. These findings suggest heterogeneity in the genetic control of tuberculosis susceptibility.
宿主遗传背景是结核病易感性的重要调节因素，这一点已得到充分证实。NRAMP1（别名SLC11A1）基因在多个种族中都与结核病易感性相关。在此，我们对来自摩洛哥卡萨布兰卡的116个核心家庭（包括211名受影响后代）进行了研究，以探讨NRAMP1与结核病之间的关联及连锁关系。所有纳入研究的结核病病例均为培养阳性。未发现NRAMP1与结核病存在连锁或关联的证据。这些发现表明，结核病易感性的遗传控制存在异质性。
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