Nie Li-xing, Jin Hong-yu, Wang Gang-li, Tian Jin-gai, Lin Rui-chao
National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China.
Zhongguo Zhong Yao Za Zhi. 2008 Dec;33(23):2764-7.
Methods for determination of heavy metals and harmful residues in traditional Chinese medicine injection were established. Graphite furnace atomic absorption spectrometry was used for determination of lead, cadmium and copper, atomic fluorescence spectrometry for arsenic and mercury. The preprocessing method was optimized. The average recoveries of 5 elements were between 91% and 112% while the precisions were less than 2%. The determination limit of lead, cadmium, copper, arsenic and mercury were 0.28, 0.014, 0.49, 0.19, 0.061 microg x L(-1), respectively. The proposed method was simple, sensitive, accurate and reliable, and could be used widely.
建立了中药注射剂中重金属及有害残留物的测定方法。采用石墨炉原子吸收光谱法测定铅、镉和铜，原子荧光光谱法测定砷和汞。对预处理方法进行了优化。5种元素的平均回收率在91%至112%之间，精密度小于2%。铅、镉、铜、砷和汞的测定限分别为0.28、0.014、0.49、0.19、0.061μg·L⁻¹。该方法简便、灵敏、准确、可靠，可广泛应用。
