Ku Xin, Huang He, Jiang Hualiang, Liu Hong
Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
J Comb Chem. 2009 May-Jun;11(3):338-40. doi: 10.1021/cc800182q.
A practical and promising protocol was developed for S-arylations of various thiols with different substituted aryl halides. The reactions were readily facilitated to afford desired thioethers under mild conditions in good to excellent yields. The versatility, air-stability, operational simplicity of this method, in addition to the higher yields and shorter reaction time it provides, highlight the potential of using this method in large scale library synthesis involving carbon-heteroatom formation.
开发了一种实用且有前景的方案，用于各种硫醇与不同取代芳基卤化物的S-芳基化反应。这些反应在温和条件下易于进行，以良好至优异的产率得到所需的硫醚。该方法的通用性、空气稳定性、操作简便性，以及它提供的更高产率和更短反应时间，突出了在涉及碳-杂原子形成的大规模文库合成中使用该方法的潜力。
