Department of Chemistry, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India.
Org Lett. 2011 Mar 4;13(5):1008-11. doi: 10.1021/ol103041s. Epub 2011 Jan 27.
An efficient Cu-catalyzed one-pot approach for the synthesis of unsymmetrical diaryl thioethers using potassium ethyl xanthogenate as a thiol surrogate is developed. This new protocol avoids usage of intricate thiols and makes use of its easily available xanthate as a precursor, and thiol will be generated in situ to prepare the diaryl thioethers through a Cu-catalyzed double arylation. This strategy was further successfully utilized for the synthesis of symmetrical diaryl thioethers, aryl alkyl thioethers, and benzothiazoles.
发展了一种使用钾乙基黄原酸钾作为硫醇替代物，通过高效的 Cu 催化一锅法合成不对称二芳基硫醚的方法。该新方法避免使用复杂的硫醇，并利用其易得的黄原酸盐作为前体，通过 Cu 催化的双芳基化原位生成硫醇来制备二芳基硫醚。该策略进一步成功地用于合成对称的二芳基硫醚、芳基烷基硫醚和苯并噻唑。
