一种实用的、两步合成2-取代1,3-丁二烯的方法。
A practical, two-step synthesis of 2-substituted 1,3-butadienes.
作者信息
Sen Sushmita, Singh Swapnil, Sieburth Scott McN
机构信息
Department of Chemistry, Temple University, 1901 North 13th Street, Philadelphia, Pennsylvania 19122, USA.
出版信息
J Org Chem. 2009 Apr 3;74(7):2884-6. doi: 10.1021/jo802737x.
Abstract
A two-step procedure for preparing 2-alkyl-1,3-butadienes is described. Cuprate addition to commercially available 1,4-dibromo-2-butene yields 3-alkyl-4-bromo-1-butene, a product of S(N)2' substitution. Dehydrohalogenation gives 2-alkyl-1,3-butadienes.
摘要
描述了一种制备2-烷基-1,3-丁二烯的两步法。将铜酸盐加成到市售的1,4-二溴-2-丁烯上得到3-烷基-4-溴-1-丁烯，这是一种SN2'取代产物。脱卤化氢得到2-烷基-1,3-丁二烯。
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