Watkins Shannon A, Maibach Howard I
Columbia College of Physicians and Surgeons, New York, NY, USA.
Contact Dermatitis. 2009 Mar;60(3):123-30. doi: 10.1111/j.1600-0536.2009.01507.x.
Irritant contact dermatitis (ICD) is common and poses a significant problem in high-risk populations. In most cases, ICD resolves despite continued exposure in a process known as 'hardening', allowing individuals to continue with their work. Those who cannot clear ICD develop chronic ICD, which is a significant source of emotional, physical, and financial distress for affected individuals. While hardening is well known among labourers and clinicians, its mechanism remains to be elucidated. Much can be learned from the study of self-healing processes like the hardening phenomenon. This overview briefly documents the pathogenesis of ICD, focuses on the latest advances pertaining to the hardening phenomenon in ICD, and then highlights potential avenues of productive research. A better understanding of the 'hardening' process in the skin will hopefully lead to advances for the treatment of ICD.
刺激性接触性皮炎（ICD）很常见，在高危人群中是一个重大问题。在大多数情况下，尽管持续接触，ICD在一个被称为“硬化”的过程中仍会消退，使个体能够继续工作。那些无法清除ICD的人会发展为慢性ICD，这对受影响的个体来说是情绪、身体和经济困扰的重要来源。虽然硬化现象在劳动者和临床医生中广为人知，但其机制仍有待阐明。从对诸如硬化现象等自我修复过程的研究中可以学到很多东西。本综述简要记录了ICD的发病机制，重点关注ICD中与硬化现象相关的最新进展，然后突出了有成效的研究的潜在途径。对皮肤“硬化”过程的更好理解有望推动ICD治疗的进展。
