Dermato-venereology Department, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia.
Occupational Medicine Department, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia.
Sci Rep. 2024 Sep 5;14(1):20702. doi: 10.1038/s41598-024-72010-0.
The use of skin barrier-enhancing topical medication is a favorable approach for the treatment of occupational hand dermatitis (OHD). Cocos nucifera or coconut oil is one of the best sources of lipid enriched with laurate acid, and glycerin is a well-known humectant that improves skin hydration. This study is aimed is to evaluate the effectiveness of C. nucifera and glycerin for secondary prevention of OHD among batik (Indonesian traditional fabric) workers. In a randomized, double-blind, crossover trial, the effect of glycerine-C. nucifera cream versus glycerin-only was considered with multiple afterwork applications of moisturizer over a 2-week period on batik workers with OHD. Assessment of trans-epidermal water loss (TEWL), skin capacitance, and a clinical assessment using the Hand Eczema Severity Index (HECSI) were carried out at day 0 and 14. The results show thirty-two batik dyeing and/or rinsing workers were enrolled in the study with mild to moderate OHD. Clinical improvement was demonstrated by 20% decrease in HECSI and TEWL, and 20% increase in skin capacitance. Both moisturizers were equally effective for the secondary prevention of OHD. As a conclusion, glycerine-C. nucifera and glycerin-only cream are equally effective for secondary prevention for OHD among batik worker to reduce the prevalence of hand dermatitis.
使用皮肤屏障增强型局部用药是治疗职业性手部皮炎（OHD）的一种有利方法。椰子或椰子油是富含月桂酸的脂质的最佳来源之一，甘油是一种众所周知的保湿剂，可改善皮肤的水分。本研究旨在评估椰子和甘油在蜡染（印度尼西亚传统织物）工人中预防 OHD 复发的效果。在一项随机、双盲、交叉试验中，在 2 周的时间内，对 OHD 蜡染工人进行多次下班后使用保湿剂，比较甘油-椰子油乳膏与仅甘油的效果。在第 0 天和第 14 天进行了经表皮水分流失（TEWL）、皮肤电容和使用手部湿疹严重指数（HECSI）进行临床评估。结果显示，有 32 名蜡染染色和/或冲洗工人患有轻度至中度 OHD。临床改善表现为 HECSI 和 TEWL 降低 20%，皮肤电容增加 20%。两种保湿剂在预防 OHD 复发方面同样有效。总之，甘油-椰子油乳膏和仅甘油乳膏在预防蜡染工人 OHD 复发方面同样有效，可降低手部皮炎的患病率。
