SpliceAid：一个关于人类中与剪接蛋白结合的实验性RNA靶基序的数据库。
SpliceAid: a database of experimental RNA target motifs bound by splicing proteins in humans.
作者信息
Piva Francesco, Giulietti Matteo, Nocchi Linda, Principato Giovanni
机构信息
Institute of Biology and Genetics, Polytechnic University of Marche, 60131, Ancona, Italy.
出版信息
Bioinformatics. 2009 May 1;25(9):1211-3. doi: 10.1093/bioinformatics/btp124. Epub 2009 Mar 4.
UNLABELLED
The correct post-transcriptional RNA processing is finely regulated by RNA-binding proteins. Unfortunately, there is little experimental information on target RNA sequences of RNA-binding proteins and moreover such experimentally derived target sequences are annotated in a compact form by the score matrices that overestimate the number of possible recognized sequences. We carried out an exhaustive hand curated literature search to create a database, SpliceAid, collecting all the experimentally assessed target RNA sequences that are bound by splicing proteins in humans. We built a web resource, database driven, to easy query SpliceAid and give back the results by an accurate and dynamic graphic representation.
AVAILABILITY
SpliceAid database is freely accessible at http://www.introni.it/splicing.html.
未标注
正确的转录后RNA加工由RNA结合蛋白精细调控。遗憾的是，关于RNA结合蛋白的靶RNA序列的实验信息很少，而且通过得分矩阵以紧凑形式注释这些实验衍生的靶序列时，会高估可能被识别的序列数量。我们进行了详尽的人工文献检索以创建一个数据库SpliceAid，收集所有经实验评估的人类剪接蛋白所结合的靶RNA序列。我们构建了一个由数据库驱动的网络资源，以便于查询SpliceAid并通过准确且动态的图形表示返回结果。
可用性
SpliceAid数据库可通过http://www.introni.it/splicing.html免费访问。
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