Braumann Chris, Guenther Nina, Wendling Peter, Engemann Rainer, Germer Christoph T, Probst Wolfgang, Mayer Hans-P, Rehnisch Bernd, Schmid Michael, Nagel Klaus, Schwenk Wolfgang
Department of General, Visceral, Vascular and Thoracic Surgery, Charité - University of Medicine, Berlin, Germany.
Dig Surg. 2009;26(2):123-9. doi: 10.1159/000206149. Epub 2009 Mar 5.
Multimodal perioperative rehabilitation in patients undergoing curative conventional colonic resection for cancer has not yet been studied in a multicenter setting. In 2005, a nationwide quality assurance program was initiated in Germany in an unselected patient population.
The prospective multicenter data collection includes patients from 24 German hospitals. All hospitals had established 'fast-track' rehabilitation as the standard perioperative treatment in elective colonic resection, and all patients entered the registry.
748 of 2,047 fast-track patients (36.5%) underwent open resection of colonic cancer. The median age of the 380 female and 368 male patients was 71 (26-96) years. Compliance was high for epidural analgesia (89%), systemic basic nonopioid analgesia (93%), 'restrictive' intraoperative intravenous fluids (81%), oral feeding (73%) and enforced mobilization (84%) on the day of surgery. Surgical complications were diagnosed in 20%, general morbidity occurred in only 13% of all patients, and 3 patients (0.4%) died in the early postoperative period. Readmission within 30 days of discharge was necessary in 27 patients (4%).
Compliance with fast-track measures was high, and general morbidity was low in a population of patients undergoing multimodal perioperative rehabilitation for conventional colonic cancer resection.
尚未在多中心环境中研究接受根治性传统结肠癌切除术患者的多模式围手术期康复情况。2005年,德国在未经过挑选的患者群体中启动了一项全国质量保证计划。
前瞻性多中心数据收集涵盖了来自24家德国医院的患者。所有医院均已将“快速康复”作为择期结肠癌切除术中的标准围手术期治疗方法,且所有患者均进入了登记系统。
2047例快速康复患者中有748例(36.5%)接受了结肠癌开放切除术。380例女性和368例男性患者的中位年龄为71岁(26 - 96岁)。硬膜外镇痛(89%)、全身性基础非阿片类镇痛(93%)、“限制性”术中静脉输液(81%)、口服喂养(73%)以及术后第一天强制活动(84%)的依从性较高。20%的患者被诊断出手术并发症,仅13%的所有患者发生了全身并发症,3例患者(0.4%)在术后早期死亡。27例患者(4%)在出院后30天内需要再次入院。
在接受传统结肠癌切除术的多模式围手术期康复患者群体中,对快速康复措施的依从性较高,且全身并发症发生率较低。