Coloproctology Unit, Department of Surgery, University Hospital of Elche, C/ Huertos y Molinos s/n., C.P. 03202, Elche, Alicante, Spain.
Int J Colorectal Dis. 2012 Dec;27(12):1637-44. doi: 10.1007/s00384-012-1497-4. Epub 2012 May 27.
The aim of this study was to see whether the application of the enhanced recovery programme for colorectal resection improves the results and, in turn, the influence of complexity and size of the hospitals in applying this and its results.
A multi-centric prospective study was controlled with a retrospective group. The prospective operation group included 300 patients with elective colorectal resection due to cancer. The centres were divided depending on size and complexity in large reference centres (group 1) and area and basic general hospitals (group 2). The retrospective control group included 201 patients with the same characteristics attended before the application of the programme. Completion of categories of the protocol, complications, perioperative mortality and stay in hospital were recorded.
The introduction of the programme achieved a reduction in mortality (1 vs. 4 %), morbidity (26 vs. 39 %) and preoperative (<24 h vs. 3 days) and postoperative (7 vs. 11 days) stays (p < 0.01). There was greater fulfilment of protocol in group 2 with the mean number of items completed at 8.46 and 60 % completed compared with the hospitals in group 1 (7.70 completed items and 55 % completion). The size of the hospital had no relation to the rate of complications (21.3 vs. 26.5 %). In smaller sized and less complex hospitals, the average length of stay was 1.88 days less than in those of greater size (6.45 vs. 8.33 days).
Patients treated according to an enhanced recovery programme develop significantly fewer complications and have a shorter hospital stay. The carrying out of protocol is greater in smaller and less complex hospitals and is directly related to a shorter stay in hospital.
本研究旨在观察结直肠切除术后应用强化康复方案是否能改善结果,并进而观察医院的复杂性和规模对应用该方案及其结果的影响。
本研究采用多中心前瞻性研究,同时设有回顾性对照组。前瞻性手术组纳入 300 例因癌症行择期结直肠切除术的患者。根据医院的规模和复杂性,将中心分为大型参考中心(第 1 组)和地区及基础综合医院(第 2 组)。回顾性对照组纳入了 201 例具有相同特征的患者,这些患者是在该方案应用之前接受治疗的。记录完成方案各分类、并发症、围手术期死亡率和住院时间。
该方案的引入使死亡率(1%比 4%)、发病率(26%比 39%)以及术前(<24 小时比 3 天)和术后(7 天比 11 天)住院时间均降低(p<0.01)。第 2 组完成方案的比例更高,平均完成项目数为 8.46 项,完成比例为 60%,而第 1 组的平均完成项目数为 7.70 项,完成比例为 55%。医院的规模与并发症发生率无关(21.3%比 26.5%)。在规模较小且较不复杂的医院,平均住院时间比规模较大的医院少 1.88 天(6.45 天比 8.33 天)。
根据强化康复方案治疗的患者发生并发症的风险显著降低,住院时间更短。在规模较小且较不复杂的医院,方案的实施程度更高,与住院时间缩短直接相关。