Ste20激酶SLK在黏附信号传导和细胞迁移中的新作用。
A novel role for the Ste20 kinase SLK in adhesion signaling and cell migration.
作者信息
Wagner Simona M, Sabourin Luc A
机构信息
Department of Cellular and Molecular Medicine, University of Ottawa and Cancer Therapeutics, Ottawa Health Research Institute, ON, CA.
出版信息
Cell Adh Migr. 2009 Apr-Jun;3(2):182-4. doi: 10.4161/cam.3.2.7229. Epub 2009 Apr 21.
With over 60 members, the Sterile 20 family of kinases has been implicated in numerous biological processes, including growth, survival, apoptosis and cell migration. Recently, we have shown that, in addition to cell death, the Ste20-like kinase SLK is required for efficient cell migration in fibroblasts. We have observed that SLK is involved in cell motility through its effect on actin reorganization and microtubule-induced focal adhesion turnover. Scratch wounding of confluent monolayers results in SLK activation. The induction of SLK kinase activity requires the scaffold FAK and a MAPK-dependent pathway. However, its recruitment to the leading edge of migrating fibroblasts requires the activity of the Src family kinases. Since SLK is microtubule-associated, it may represent one of the signals delivered to focal contacts that induces adhesions turnover. A speculative model is proposed to illustrate the mechanism of SLK activation and recruitment at the leading edge of migrating cells.
激酶的无菌20家族拥有60多个成员，参与了众多生物学过程，包括生长、存活、细胞凋亡和细胞迁移。最近，我们发现，除了细胞死亡外，类Ste20激酶SLK对于成纤维细胞的高效迁移也是必需的。我们观察到，SLK通过影响肌动蛋白重组和微管诱导的粘着斑周转来参与细胞运动。汇合单层细胞的划痕损伤会导致SLK激活。SLK激酶活性的诱导需要支架蛋白FAK和一条MAPK依赖的信号通路。然而，它被招募到迁移成纤维细胞的前沿需要Src家族激酶的活性。由于SLK与微管相关，它可能代表传递至粘着斑的诱导粘着斑周转的信号之一。我们提出了一个推测模型来说明SLK在迁移细胞前沿的激活和招募机制。
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