大剂量甲氨蝶呤：基本原理 - Suppr | 超能文献

High-dose methotrexate: the rationale..

作者信息

Cheok Meyling H, Evans William E, Kager Leo

出版信息

J Pediatr Hematol Oncol. 2009 Mar;31(3):224-5. doi: 10.1097/MPH.0b013e318196a2a6.

DOI:10.1097/MPH.0b013e318196a2a6

Abstract

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High-dose methotrexate: the rationale..大剂量甲氨蝶呤：基本原理

J Pediatr Hematol Oncol. 2009 Mar;31(3):224-5. doi: 10.1097/MPH.0b013e318196a2a6.

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Population Pharmacokinetic Study and Individual Dose Adjustments of High-Dose Methotrexate in Chinese Pediatric Patients With Acute Lymphoblastic Leukemia or Osteosarcoma.中国儿童急性淋巴细胞白血病或骨肉瘤患者大剂量甲氨蝶呤的群体药代动力学研究与个体化剂量调整。

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High-dose methotrexate is lethal to rats. Why give it to children?高剂量甲氨蝶呤对大鼠是致命的。为什么要给儿童使用呢？

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[Toxicity of high dose methotrexate repeated infusions in children treated for acute lymphoblastic leukemia and osteosarcoma].[高剂量甲氨蝶呤重复输注对急性淋巴细胞白血病和骨肉瘤患儿的毒性作用]

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High-dose methotrexate is effective in osteosarcoma so what is the problem?高剂量甲氨蝶呤对骨肉瘤有效，那么问题出在哪里呢？

J Pediatr Hematol Oncol. 2009 Dec;31(12):892-4. doi: 10.1097/MPH.0b013e3181c29c66.

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Outpatient high-dose methotrexate: proceed with extreme caution, if at all.门诊高剂量甲氨蝶呤治疗：若非必要，务必极其谨慎地进行。

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Neoadjuvant chemotherapy with high-dose methotrexate in osteosarcoma.骨肉瘤中高剂量甲氨蝶呤的新辅助化疗。

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[Assessment of elimination and tolerance of high dose of methotrexate (3 g/m2) in children with standard-risk acute lymphoblastic leukemia].[标准风险急性淋巴细胞白血病患儿高剂量甲氨蝶呤（3 g/m²）的清除率及耐受性评估]

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Influence of methotrexate dose intensity on outcome of patients with high grade osteogenic osteosarcoma: analysis of the literature.甲氨蝶呤剂量强度对高级别成骨性骨肉瘤患者预后的影响：文献分析

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High-dose methotrexate in fibroblastic osteosarcoma.高剂量甲氨蝶呤治疗成纤维细胞型骨肉瘤

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