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硒和维生素E可调节香烟烟雾暴露诱导的大鼠血液氧化应激。

Selenium and vitamin E modulates cigarette smoke exposure-induced oxidative stress in blood of rats.

作者信息

Cay Mehmet, Naziroğlu Mustafa, Köylü Halis

机构信息

Department of Physiology, Veterinary Faculty, Firat University, Elaziğ, Turkey.

出版信息

Biol Trace Elem Res. 2009 Oct;131(1):62-70. doi: 10.1007/s12011-009-8347-4. Epub 2009 Mar 5.

Abstract

Cigarette smoke contains about 5,000 chemicals that include organic and metallic compounds. The current study was undertaken to investigate the effects of selenium and vitamin E on oxidative stress-induced damage in rats exposed to cigarette smoke. Forty male rats were equally divided into four groups. The first and second groups were used as control and cigarette smoke groups, respectively. Selenium was administered to rats constituting the third group for 27 days. The Se and vitamin E combination was given to animals in fourth group for 27 days. All groups except the control, were exposed to cigarette smoke starting at the third day of the experiment and continuing for 27 days. The blood samples from all groups were taken at the end of 27 days. Plasma lipid peroxidation, triacylglycerol, and total cholesterol levels were higher in the cigarette smoke group than in the control, although erythrocytic superoxide dismutase and glutathione peroxidase activities were lower in the cigarette smoke group than in the control. The plasma lipid peroxidation, triacylglycerol, and total cholesterol levels were lower in cigarette smoke+Se+VE group than in the cigarette smoke group, although erythrocytic superoxide dismutase activity and glutathione peroxidase activity in selenium and vitamin E-administered groups were higher than in the exposed to cigarette smoke group. High-density lipoprotein-cholesterol level was not affect by selenium and vitamin E administrations. In conclusion, selenium and vitamin E seem to have protective effects on the cigarette smoke-induced blood toxicity by supporting the enzymatic antioxidant redox systems.

摘要

香烟烟雾含有约5000种化学物质,包括有机化合物和金属化合物。本研究旨在探讨硒和维生素E对暴露于香烟烟雾的大鼠氧化应激诱导损伤的影响。40只雄性大鼠平均分为四组。第一组和第二组分别作为对照组和香烟烟雾组。第三组大鼠给予硒27天。第四组动物给予硒和维生素E联合用药27天。除对照组外,所有组从实验第3天开始暴露于香烟烟雾中,持续27天。27天结束时采集所有组的血样。香烟烟雾组的血浆脂质过氧化、三酰甘油和总胆固醇水平高于对照组,而香烟烟雾组的红细胞超氧化物歧化酶和谷胱甘肽过氧化物酶活性低于对照组。香烟烟雾+硒+维生素E组的血浆脂质过氧化、三酰甘油和总胆固醇水平低于香烟烟雾组,而给予硒和维生素E组的红细胞超氧化物歧化酶活性和谷胱甘肽过氧化物酶活性高于暴露于香烟烟雾组。高密度脂蛋白胆固醇水平不受硒和维生素E给药的影响。总之,硒和维生素E似乎通过支持酶促抗氧化还原系统对香烟烟雾诱导的血液毒性具有保护作用。

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