Grinna L S
Gerontology. 1977;23(5):342-9. doi: 10.1159/000212206.
Arrhenius plots of glucose-6-phosphatase (EC 3.1.3.9) activity in liver microsomes from 6-month-old rats (young) showed discontinuities at 39, 30, 20 and 12 degrees C and change in activation energy at 20 degrees C. The enzyme activity in kidney microsomes of young rats showed essentially the same thermal discontinuities. In liver microsomes of 24-month-old rats (old) the enzyme showed discontinuities at 38, 30, 24 and 16 degrees C but not at 12 degrees C and the activation energy changed at 24 degrees C. In kidney microsomes of old rats discontinuities were seen at 38, 31, 22, 16 and 12 degrees C and the activation energy was constant from 0 to 41 degrees C. These results indicate that the interactions of membrane components are altered with age.
对6月龄大鼠（年轻大鼠）肝脏微粒体中葡萄糖-6-磷酸酶（EC 3.1.3.9）活性进行的阿累尼乌斯曲线分析显示，在39、30、20和12℃出现间断，且在20℃时活化能发生变化。年轻大鼠肾脏微粒体中的酶活性显示出基本相同的热间断。在24月龄大鼠（老年大鼠）的肝脏微粒体中，该酶在38、30、24和16℃出现间断，但在12℃未出现间断，且在24℃时活化能发生变化。在老年大鼠的肾脏微粒体中，在38、31、22、16和12℃出现间断，且活化能在0至41℃范围内保持恒定。这些结果表明，膜成分之间的相互作用随年龄而改变。
