葫芦（Lau）果实中一种多糖的结构鉴定及细胞毒性活性
Structural identification and cytotoxic activity of a polysaccharide from the fruits of Lagenaria siceraria (Lau).
作者信息
Ghosh Kaushik, Chandra Krishnendu, Ojha Arnab K, Sarkar Siddik, Islam Syed S
机构信息
Department of Chemistry and Chemical Technology, Vidyasagar University, Midnapore 721 102, West Bengal, India.
出版信息
Carbohydr Res. 2009 Mar 31;344(5):693-8. doi: 10.1016/j.carres.2009.01.012. Epub 2009 Jan 19.
A water-soluble polysaccharide, isolated from fruiting bodies of Lagenaria siceraria, is composed of methyl-alpha-d-galacturonate, 3-O-acetyl methyl-alpha-d-galacturonate, and beta-d-galactose in a ratio of nearly 1:1:1. Compositional analysis, methylation analysis, periodate oxidation, and NMR studies ((1)H, (13)C, 2D-COSY, TOCSY, NOESY, HMQC, and HMBC) revealed the presence of the following repeating unit in the polysaccharide: [carbohydrate structure: see text] This polysaccharide showed cytotoxic activity in vitro against human breast adenocarcinoma cell line (MCF-7).
从葫芦的子实体中分离出的一种水溶性多糖，由甲基-α-D-半乳糖醛酸、3-O-乙酰基甲基-α-D-半乳糖醛酸和β-D-半乳糖以近1:1:1的比例组成。组成分析、甲基化分析、高碘酸盐氧化和核磁共振研究（（1）H、（13）C、二维COSY、TOCSY、NOESY、HMQC和HMBC）表明该多糖中存在以下重复单元：[碳水化合物结构：见正文] 这种多糖在体外对人乳腺腺癌细胞系（MCF-7）显示出细胞毒性活性。
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