Keir J, Clarke R
Department of Otolaryngology, North Cheshire Hospitals NHS Trust, Lovely Lane, Warrington, WA5 1QG, UK.
Int J Pediatr Otorhinolaryngol. 2009 Oct;73(10):1321-4. doi: 10.1016/j.ijporl.2009.02.002. Epub 2009 Mar 4.
To review the current evidence for the use of concomitant interventions to reduce the persistent perforation rate following the removal of long-term ventilation tubes.
A systematic review of the literature and meta-analysis of randomised controlled trials on this topic.
Medline (1952-2008), EMBASE (1974-2008) and the Cochrane Central Register of Controlled Trials. A combination of search terms were used in a search strategy derived from guidance from the Cochrane collaboration.
A review of all trials by two authors with grading of the level of evidence.
Fifteen studies using a variety of interventions were identified.
A multi-centre randomised controlled trial is indicated to validate findings of previous studies and elucidate any optimum intervention to reduce the persistent perforation rate.
回顾目前关于采用联合干预措施降低长期通气导管拔除后持续性穿孔率的证据。
对该主题的文献进行系统综述并对随机对照试验进行荟萃分析。
检索Medline（1952 - 2008年）、EMBASE（1974 - 2008年）以及Cochrane对照试验中央注册库。采用从Cochrane协作网指南衍生而来的检索策略，使用了多种检索词组合。
由两位作者对所有试验进行综述，并对证据水平进行分级。
共识别出15项采用各种干预措施的研究。
需要进行一项多中心随机对照试验，以验证先前研究的结果，并阐明任何降低持续性穿孔率的最佳干预措施。
