成像癌基因表达。
Imaging oncogene expression.
作者信息
Mukherjee Archana, Wickstrom Eric, Thakur Mathew L
机构信息
Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
出版信息
Eur J Radiol. 2009 May;70(2):265-73. doi: 10.1016/j.ejrad.2009.01.043. Epub 2009 Mar 4.
Abstract
This review briefly outlines the importance of molecular imaging, particularly imaging of endogenous gene expression for noninvasive genetic analysis of radiographic masses. The concept of antisense imaging agents and the advantages and challenges in the development of hybridization probes for in vivo imaging are described. An overview of the investigations on oncogene expression imaging is given. Finally, the need for further improvement in antisense-based imaging agents and directions to improve oncogene mRNA targeting is stated.
摘要
本综述简要概述了分子成像的重要性，特别是用于对影像学肿块进行无创基因分析的内源性基因表达成像。描述了反义成像剂的概念以及用于体内成像的杂交探针开发中的优势和挑战。给出了癌基因表达成像研究的概述。最后，阐述了基于反义的成像剂进一步改进的必要性以及改善癌基因mRNA靶向的方向。
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