Win Z, Al-Nahhas A, Rubello D, Gross M D
Department of Nuclear Medicine, Hammersmith Hospital, London, UK.
Q J Nucl Med Mol Imaging. 2007 Sep;51(3):244-50. Epub 2007 Apr 30.
Imaging somatostatin receptor status with 68Ga labeled peptides has progressed rapidly over the last several years. It has generated great interest, and stimulated further research into the development of DOTA-derivative peptides. It has expanded our knowledge of receptor imaging and enhanced our appreciation of the difference between receptor-based and metabolic imaging, as well as more in-depth evaluation of tumor biology. The availability of the 68Ge/68Ga generator provides an attractive alternative to cyclotron-based positron-emitters, especially if kit-based radiopharmaceutical formulations based upon 68Ga are developed in the future.
在过去几年中，利用68Ga标记的肽类进行生长抑素受体显像发展迅速。它引起了极大的关注，并刺激了对DOTA衍生肽类开发的进一步研究。它扩展了我们对受体显像的认识，增强了我们对基于受体的显像与代谢显像之间差异的理解，以及对肿瘤生物学更深入的评估。68Ge/68Ga发生器的出现为基于回旋加速器的正电子发射体提供了一个有吸引力的替代方案，特别是如果未来能开发出基于68Ga的试剂盒型放射性药物制剂的话。
