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本文引用的文献

1
Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor.芳烃受体对调节性T细胞和辅助性T细胞17分化的调控
Nature. 2008 May 1;453(7191):65-71. doi: 10.1038/nature06880. Epub 2008 Mar 23.
2
Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature.调节性T细胞转录特征的Foxp3转录因子依赖性和非依赖性调控
Immunity. 2007 Nov;27(5):786-800. doi: 10.1016/j.immuni.2007.09.010.
3
Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells.非自身抗原是Foxp3 +调节性T细胞的同源特异性。
Immunity. 2007 Sep;27(3):493-504. doi: 10.1016/j.immuni.2007.07.019.
4
TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets.基于TCR的谱系追踪：没有证据表明常规T细胞会因胰腺胰岛中的天然自身抗原而转化为调节性T细胞。
J Exp Med. 2007 Sep 3;204(9):2039-45. doi: 10.1084/jem.20070822. Epub 2007 Aug 27.
5
DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells.人类FOXP3基因座中的DNA去甲基化可区分调节性T细胞与活化的FOXP3(+)传统T细胞。
Eur J Immunol. 2007 Sep;37(9):2378-89. doi: 10.1002/eji.200737594.
6
Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes.在未成熟胸腺细胞中，Ikaros和Helios与核小体重塑去乙酰化酶复合物（NuRD复合物）的主要相互作用。
J Biol Chem. 2007 Oct 12;282(41):30227-38. doi: 10.1074/jbc.M702541200. Epub 2007 Aug 6.
7
Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans.用于人类对自身抗原和同种异体抗原产生耐受性的调节性T细胞免疫疗法。
Nat Rev Immunol. 2007 Aug;7(8):585-98. doi: 10.1038/nri2138.
8
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid.小肠固有层树突状细胞通过视黄酸促进Foxp3调节性T细胞的从头生成。
J Exp Med. 2007 Aug 6;204(8):1775-85. doi: 10.1084/jem.20070602. Epub 2007 Jul 9.
9
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism.一群功能特化的黏膜CD103⁺树突状细胞通过转化生长因子-β和视黄酸依赖机制诱导Foxp3⁺调节性T细胞。
J Exp Med. 2007 Aug 6;204(8):1757-64. doi: 10.1084/jem.20070590. Epub 2007 Jul 9.
10
Ligand-independent regulation of transforming growth factor beta1 expression and cell cycle progression by the aryl hydrocarbon receptor.芳烃受体对转化生长因子β1表达和细胞周期进程的非配体依赖性调节
Mol Cell Biol. 2007 Sep;27(17):6127-39. doi: 10.1128/MCB.00323-07. Epub 2007 Jul 2.

诱导性调节性T细胞在实验性结肠炎耐受诱导中的核心作用。

A central role for induced regulatory T cells in tolerance induction in experimental colitis.

作者信息

Haribhai Dipica, Lin Wen, Edwards Brandon, Ziegelbauer Jennifer, Salzman Nita H, Carlson Marc R, Li Shun-Hwa, Simpson Pippa M, Chatila Talal A, Williams Calvin B

机构信息

Department of Pediatrics, Section of Rheumatology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

出版信息

J Immunol. 2009 Mar 15;182(6):3461-8. doi: 10.4049/jimmunol.0802535.

DOI:10.4049/jimmunol.0802535
PMID:19265124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2763205/
Abstract

In addition to thymus-derived or natural T regulatory (nT(reg)) cells, a second subset of induced T regulatory (iT(reg)) cells arises de novo from conventional CD4(+) T cells in the periphery. The function of iT(reg) cells in tolerance was examined in a CD45RB(high)CD4(+) T cell transfer model of colitis. In situ-generated iT(reg) cells were similar to nT(reg) cells in their capacity to suppress T cell proliferation in vitro and their absence in vivo accelerated bowel disease. Treatment with nT(reg) cells resolved the colitis, but only when iT(reg) cells were also present. Although iT(reg) cells required Foxp3 for suppressive activity and phenotypic stability, their gene expression profile was distinct from the established nT(reg) "genetic signature," indicative of developmental and possibly mechanistic differences. These results identified a functional role for iT(reg) cells in vivo and demonstrated that both iT(reg) and nT(reg) cells can act in concert to maintain tolerance.

摘要

除了胸腺来源的或天然的调节性T细胞（nT(reg)细胞）外，诱导性调节性T细胞（iT(reg)细胞）的第二个亚群在外周由传统的CD4(+) T细胞重新产生。在结肠炎的CD45RB(high)CD4(+) T细胞转移模型中检测了iT(reg)细胞在耐受性方面的功能。原位产生的iT(reg)细胞在体外抑制T细胞增殖的能力方面与nT(reg)细胞相似，并且它们在体内的缺失会加速肠道疾病。用nT(reg)细胞治疗可缓解结肠炎，但只有当iT(reg)细胞也存在时才行。虽然iT(reg)细胞的抑制活性和表型稳定性需要Foxp3，但它们的基因表达谱与已确定的nT(reg)“基因特征”不同，这表明存在发育差异以及可能的机制差异。这些结果确定了iT(reg)细胞在体内的功能作用，并证明iT(reg)细胞和nT(reg)细胞都可以协同作用以维持耐受性。