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一项病例对照研究,旨在探究苏拉特市洪水过后感染钩端螺旋体病的风险因素。

A case control study to explore the risk factors for acquisition of leptospirosis in Surat city, after flood.

作者信息

Bhardwaj Pankaj, Kosambiya J K, Desai Vikas K

机构信息

Department of Community Medicine, Era's Lucknow Medical College & Hospital, Lucknow, India.

出版信息

Indian J Med Sci. 2008 Nov;62(11):431-8.

Abstract

BACKGROUND

Between August and November 2006, a population-based case control study was conducted to identify the probable risk factors for leptospirosis during flooding in Surat city.

MATERIALS AND METHODS

Sixty-two laboratory confirmed cases out of 129 suspected cases, and 253 age and sex matched fever and healthy controls were interviewed with the help of predesigned questionnaire. The association of risk factors with acquiring leptospirosis was assessed by adjusted OR with the help of logistic regression model to control confounders.

RESULTS

By univariate analysis, factors identified were, walking barefoot (OR = 10.34, 95% CI 5.09-21.31, P <0.05).

CONCLUSIONS

Prompt and vigilant fever surveillance activities in pre-monsoon preparedness plan, intensive IEC messages, rodent control programs and improvement of environmental sanitary conditions may help to greatly reduce the incidence of leptospirosis.

摘要

背景

2006年8月至11月,在苏拉特市开展了一项基于人群的病例对照研究,以确定洪灾期间钩端螺旋体病的可能危险因素。

材料与方法

在预先设计的问卷的帮助下,对129例疑似病例中的62例实验室确诊病例以及253例年龄和性别匹配的发热患者及健康对照进行了访谈。借助逻辑回归模型,通过调整后的比值比评估危险因素与感染钩端螺旋体病的关联,以控制混杂因素。

结果

单因素分析确定的因素为赤足行走(比值比=10.34,95%可信区间5.09-21.31,P<0.05)。

结论

在季风前防备计划中开展及时且警惕的发热监测活动、强化信息教育与宣传、灭鼠计划以及改善环境卫生条件,可能有助于大幅降低钩端螺旋体病的发病率。

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