Fujita Naoto, Fujimoto Taro, Tasaki Hiromitsu, Arakawa Takamitsu, Matsubara Takako, Miki Akinori
Department of Rehabilitation Sciences, Kobe University Graduate School of Health Sciences, Kobe, Japan.
Biomed Res. 2009 Feb;30(1):39-45. doi: 10.2220/biomedres.30.39.
The tibialis anterior and soleus muscles were fixed at the stretched or shortened positions to examine the influence of muscle length on muscle atrophy. Mice were divided into control (C), hindlimb suspension (HS), hindlimb suspension with ankle joint fixation at the maximum dorsiflexion (HSD), and hindlimb suspension with ankle joint fixation at the maximum plantarflexion (HSP). During the hindlimb suspension, the length of these muscles in the HS and HSP groups was very similar. Fourteen days after the hindlimb suspension, the atrophy of the tibialis anterior muscle in the HS and HSP groups was evidently milder than that in the HSD group, and that in the HS and HSP groups was very similar, suggesting that atrophy of the tibialis anterior muscle might largely depend on muscle length. Atrophy of the soleus muscle in the HSD group was milder than that in the HS and HSP groups, indicating that atrophy of the soleus muscle might also depend on muscle length. But atrophy of this muscle in the HSP group was milder than that in the HS group. These results demonstrate that some factors induced by the joint immobilization might be effective in preventing atrophy of the soleus muscle.
将胫骨前肌和比目鱼肌固定在拉伸或缩短位置，以研究肌肉长度对肌肉萎缩的影响。将小鼠分为对照组（C）、后肢悬吊组（HS）、踝关节固定于最大背屈位的后肢悬吊组（HSD）和踝关节固定于最大跖屈位的后肢悬吊组（HSP）。在后肢悬吊期间，HS组和HSP组中这些肌肉的长度非常相似。后肢悬吊14天后，HS组和HSP组胫骨前肌的萎缩明显轻于HSD组，且HS组和HSP组非常相似，这表明胫骨前肌的萎缩可能很大程度上取决于肌肉长度。HSD组比目鱼肌的萎缩轻于HS组和HSP组，表明比目鱼肌的萎缩也可能取决于肌肉长度。但HSP组该肌肉的萎缩轻于HS组。这些结果表明，关节固定诱导的一些因素可能对预防比目鱼肌萎缩有效。
