Persson Anders I, Weiss William A
Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
Cell Stem Cell. 2009 Mar 6;4(3):191-2. doi: 10.1016/j.stem.2009.02.004.
In this issue of Cell Stem Stell, Bleau et al. report that activity of the drug transporter ABCG2 defines a tumorigenic stem-like side population (SP) isolated from glioma. Surprisingly, temozolomide, the first-line chemotherapeutic used for treatment of glioma, increased this side population, and even more so when PTEN was deleted.
在本期《细胞·干细胞》杂志中，布勒奥等人报告称，药物转运蛋白ABCG2的活性定义了一种从胶质瘤中分离出来的具有致瘤性的干细胞样侧群（SP）。令人惊讶的是，用于治疗胶质瘤的一线化疗药物替莫唑胺增加了这个侧群，当PTEN缺失时更是如此。
