一种作为哈维氏弧菌群体感应抑制剂的新型吩噻嗪结构骨架。
A new phenothiazine structural scaffold as inhibitors of bacterial quorum sensing in Vibrio harveyi.
作者信息
Ni Nanting, Choudhary Gaurav, Li Minyong, Wang Binghe
机构信息
Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Campus Box 4098, Atlanta, GA 30302-4098, USA.
出版信息
Biochem Biophys Res Commun. 2009 Apr 24;382(1):153-6. doi: 10.1016/j.bbrc.2009.02.157. Epub 2009 Mar 4.
Quorum sensing has attracted much attention due to its involvement in pathologically relevant events such as biofilm formation, virulence factor production, and sporulation. Inhibitors of quorum sensing are important research tools and potential therapeutic agents. In this paper, we describe a phenothiazine structural scaffold as a new type of quorum sensing inhibitors with IC(50) values in the single digit micro molar range in Vibrio harveyi.
群体感应因其参与生物膜形成、毒力因子产生和孢子形成等与病理相关的事件而备受关注。群体感应抑制剂是重要的研究工具和潜在的治疗药物。在本文中，我们描述了一种吩噻嗪结构骨架作为新型群体感应抑制剂，其对哈维氏弧菌的半数抑制浓度（IC50）值在个位数微摩尔范围内。
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