Defoirdt Tom, Boon Nico, Sorgeloos Patrick, Verstraete Willy, Bossier Peter
Laboratory of Microbial Ecology and Technology (LabMET), Ghent University, Ghent, Belgium.
ISME J. 2008 Jan;2(1):19-26. doi: 10.1038/ismej.2007.92. Epub 2007 Oct 25.
Luminescent vibrios, bacteria belonging to the species Vibrio harveyi and closely related species, are important pathogens in aquaculture that can affect almost all types of cultured animals. Due to large-scale use of antibiotics, many luminescent vibrios have acquired (multiple) resistance, which render antibiotic treatments ineffective. One of the alternative strategies that has recently been developed to control infections caused by antibiotic-resistant bacteria is the disruption of quorum sensing, bacterial cell-to-cell communication. The quorum sensing system of V. harveyi has been studied quite intensively in vitro. Recent studies have been directed towards understanding the impact of quorum sensing and quorum sensing disruption on the virulence of luminescent vibrios towards different host organisms in vivo. This mini-review aims at discussing the current knowledge of quorum sensing in luminescent vibrios in vivo. Subsequently, quorum quenching by halogenated furanones is discussed and finally, some directions for further research are presented.
发光弧菌，属于哈维氏弧菌及其近缘物种，是水产养殖中的重要病原体，可影响几乎所有类型的养殖动物。由于抗生素的大规模使用，许多发光弧菌已获得（多重）抗性，这使得抗生素治疗无效。最近开发的用于控制由抗生素抗性细菌引起的感染的替代策略之一是破坏群体感应，即细菌细胞间的通讯。哈维氏弧菌的群体感应系统已在体外进行了深入研究。最近的研究旨在了解群体感应和群体感应破坏对发光弧菌在体内对不同宿主生物体毒力的影响。本综述旨在讨论目前关于发光弧菌体内群体感应的知识。随后，讨论了卤代呋喃酮的群体猝灭作用，最后提出了一些进一步研究的方向。
