壳聚糖接枝聚对二氧环己酮共聚物：制备、表征及性能

Chitosan-graft poly(p-dioxanone) copolymers: preparation, characterization, and properties.

作者信息

Wang Xiu-Li, Huang Yan, Zhu Jiang, Pan Yan-Bo, He Rui, Wang Yu-Zhong

机构信息

Center for Degradable and Flame-Retardant Polymeric Materials (ERCEPM-MoE), College of Chemistry, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610064, China.

出版信息

Carbohydr Res. 2009 Apr 21;344(6):801-7. doi: 10.1016/j.carres.2009.02.009. Epub 2009 Feb 13.

DOI:10.1016/j.carres.2009.02.009

PMID:19268919

Abstract

A new biodegradable copolymer of chitosan and poly(p-dioxanone) (PPDO) was prepared through a protection-graft-deprotection procedure using N-phthaloyl-chitosan as an intermediate. PPDO terminated with the isocyanate group was allowed to react with hydroxyl groups of the N-phthaloyl-protected chitosan, and then the phthaloyl group was cleaved to give the free amino groups. The length of PPDO graft chains can be controlled easily by using the prepolymers of PPDO with different molecular weights. The resulting products were thoroughly characterized with FT-IR, (1)H NMR, TG, DSC, SEM, and WAXD. The copolymers were used as drug carriers for sinomenine (7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-9alpha,13alpha,14alpha-morphinan-6-one) and these exhibited a significant controlled drug-releasing behavior whether in artificial gastric juice or in neutral phosphate buffer solution.

摘要

通过以N-邻苯二甲酰壳聚糖为中间体的保护-接枝-脱保护过程，制备了一种新型的壳聚糖与聚对二氧环己酮（PPDO）的可生物降解共聚物。使异氰酸酯基封端的PPDO与N-邻苯二甲酰保护的壳聚糖的羟基反应，然后裂解邻苯二甲酰基以得到游离氨基。通过使用不同分子量的PPDO预聚物，可以轻松控制PPDO接枝链的长度。用傅里叶变换红外光谱（FT-IR）、核磁共振氢谱（¹H NMR）、热重分析（TG）、差示扫描量热法（DSC）、扫描电子显微镜（SEM）和广角X射线衍射（WAXD）对所得产物进行了全面表征。这些共聚物用作青藤碱（7,8-二脱氢-4-羟基-3,7-二甲氧基-17-甲基-9α,13α,14α-吗啡喃-6-酮）的药物载体，无论在人工胃液还是中性磷酸盐缓冲溶液中，均表现出显著的控释药物行为。