新型方法合成磷酸化壳聚糖及其表征
Synthesis of phosphorylated chitosan by novel method and its characterization.
作者信息
Jayakumar R, Nagahama H, Furuike T, Tamura H
机构信息
Faculty of Chemistry, Materials and Bioengineering and HRC, Kansai University, Osaka 564-8680, Japan.
出版信息
Int J Biol Macromol. 2008 May 1;42(4):335-9. doi: 10.1016/j.ijbiomac.2007.12.011. Epub 2008 Jan 10.
Chitosan a natural based polymer is non-toxic, biocompatible and biodegradable. Chemical modification of chitosan to generate new bifunctional materials and finally would bring new properties depending on the nature of the group introduced. In our present study, we prepared phosphorylated chitosan (P-chitosan) by using H(3)PO(4)/P(2)O(5)/Et(3)PO(4)/hexanol method. From our present method, we got high yield and high degree of substitution (DS). The prepared P-chitosan (DS-1.18) was characterized by FT IR, (13)C NMR, (31)P NMR, elemental, XRD, TGA, DTA and SEM studies. After the phosphorylation, the solubility of the polymer was improved. The P-chitosan showed less thermal stability and crystallinity than the chitosan. It was due to the phosphorylation.
壳聚糖是一种天然聚合物，无毒、具有生物相容性且可生物降解。对壳聚糖进行化学改性以生成新的双功能材料，最终会根据引入基团的性质带来新的特性。在我们目前的研究中，我们使用H(3)PO(4)/P(2)O(5)/Et(3)PO(4)/己醇法制备了磷酸化壳聚糖（P-壳聚糖）。通过我们目前的方法，我们获得了高产率和高取代度（DS）。通过傅里叶变换红外光谱（FT IR）、碳-13核磁共振（(13)C NMR）、磷-31核磁共振（(31)P NMR）、元素分析、X射线衍射（XRD）、热重分析（TGA）、差示热分析（DTA）和扫描电子显微镜（SEM）研究对制备的P-壳聚糖（DS-1.18）进行了表征。磷酸化后，聚合物的溶解度提高。P-壳聚糖的热稳定性和结晶度比壳聚糖低。这是由于磷酸化所致。
Zotero 插件