Duan Wengui, Shen Changmao, Fang Huaxiang, Li Guang Hua
School of Chemistry and Chemical Engineering, Guangxi University, No. 100, Daxue Road, Nanning, Guangxi 530004, People's Republic of China.
Carbohydr Res. 2009 Jan 5;344(1):9-13. doi: 10.1016/j.carres.2008.08.007. Epub 2008 Aug 14.
A new type of chitosan derivative, dehydroabietic acid-modified chitosan (DAMC), was synthesized by the acylation reaction of chitosan with dehydroabietic acid chloride (DHAC) under microwave irradiation. The resulting product (DAMC) was characterized by FT-IR, UV, (1)H NMR, X-ray diffraction (XRD), scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), and elemental analysis. The degree of substitution (DS) of DAMC was 16.5%. And chitosan and DAMC were used as carriers of fenoprofen calcium (FC), and their controlled release behavior in artificial intestinal juice was studied. The results showed that the controlled release of FC from the carrier of DAMC is better than that from original chitosan.
通过壳聚糖与脱氢枞酸酰氯（DHAC）在微波辐射下的酰化反应，合成了一种新型壳聚糖衍生物——脱氢枞酸改性壳聚糖（DAMC）。采用傅里叶变换红外光谱（FT-IR）、紫外光谱（UV）、核磁共振氢谱（¹H NMR）、X射线衍射（XRD）、扫描电子显微镜（SEM）、热重分析（TGA）和元素分析对所得产物（DAMC）进行了表征。DAMC的取代度（DS）为16.5%。以壳聚糖和DAMC作为非诺洛芬钙（FC）的载体，研究了它们在人工肠液中的控释行为。结果表明，FC从DAMC载体中的控释效果优于从原始壳聚糖中的控释效果。
