Seggewiss H, Fassbender D, Gleichmann U, Mannebach H, Vogt J, Minami K
Kardiologische Klinik, Ruhr-Universität Bochum, Bad Oeynhausen.
Z Kardiol. 1991 Jul;80(7):423-30.
Percutaneous transluminal coronary angioplasty (PTCA) of patients with unstable angina pectoris is an established therapy, although the rate of major complications (death, myocardial infarction, emergency coronary artery bypass operation) is higher than in patients with stable angina. This study analyzes the results of PTCA in 168 patients (136 men, 32 women, mean age 60.6 +/- 9.6 years) treated between January 1989 and June 1990 for unstable angina pectoris. Unstable angina was classified according to the criteria proposed by Braunwald in 1989. PTCA was successful in 141 patients (83.9%) and failed in 27 patients (16.1%). No patient died. One patient (0.6%) suffered an acute myocardial infarction related to PTCA. After failed PTCA 16 patients (9.5%) underwent emergency coronary artery bypass grafting (CABG), 10 patients had no complication. In patients of unstable angina class III (angina at rest within the last 48 h before PTCA) emergency CABG was needed in 20.3% compared to 3.6% (p less than 0.01) in patients with unstable angina class II (last attack of angina at rest more than 48 h before PTCA). Also 30% of patients with unstable angina within 2 weeks after myocardial infarction (clinical subgroup C) needed emergency CABG after failed PTCA as compared to only 6.9% (p less than 0.01) of patients with primary unstable angina pectoris without previous infarction (clinical subgroup B). The highest frequency (66.6%/6 of 9 patients) of emergency CABG was observed in patients with class III and subgroup C. We conclude that the classification of unstable angina pectoris proposed by Braunwald might be helpful to identify patients with risk in PTCA.(ABSTRACT TRUNCATED AT 250 WORDS)
经皮腔内冠状动脉成形术(PTCA)是不稳定型心绞痛患者的一种既定治疗方法,尽管主要并发症(死亡、心肌梗死、急诊冠状动脉搭桥手术)的发生率高于稳定型心绞痛患者。本研究分析了1989年1月至1990年6月期间接受治疗的168例不稳定型心绞痛患者(136例男性,32例女性,平均年龄60.6±9.6岁)的PTCA结果。不稳定型心绞痛根据1989年Braunwald提出的标准进行分类。141例患者(83.9%)PTCA成功,27例患者(16.1%)失败。无患者死亡。1例患者(0.6%)发生与PTCA相关的急性心肌梗死。PTCA失败后,16例患者(9.5%)接受了急诊冠状动脉搭桥术(CABG),10例患者无并发症。在不稳定型心绞痛III级患者(PTCA前最后48小时内静息性心绞痛)中,20.3%需要急诊CABG,而不稳定型心绞痛II级患者(PTCA前最后一次静息性心绞痛发作超过48小时)中这一比例为3.6%(p<0.01)。心肌梗死后2周内的不稳定型心绞痛患者(临床亚组C)中,30%在PTCA失败后需要急诊CABG,而无前次梗死的原发性不稳定型心绞痛患者(临床亚组B)中这一比例仅为6.9%(p<0.01)。急诊CABG发生率最高(9例患者中的6例,66.6%)的是III级和亚组C的患者。我们得出结论,Braunwald提出的不稳定型心绞痛分类可能有助于识别PTCA中有风险的患者。(摘要截短于250字)