Fenchel G, Karsch K R, Seboldt H, Michel J, Völker W, Hoffmeister H E
Abteilung Thorax-, Herz- und Gefässchirurgie der Chirurgischen Klinik,Universität Tübingen, FRG.
Helv Chir Acta. 1990 Oct;57(2):359-63.
During a 4-year period from January 1985 to December 1988 140 patients underwent percutaneous transluminal coronary angioplasty (PTCA) of the culprit-vessel for unstable angina. Seventeen patients (12%) needed emergency aorta coronary bypass surgery (ACVB) for failed angioplasty. In 15 cases the culprit-vessel was the LAD and in 2 cases a dominant right coronary artery. Only in 2 cases a history of myocardial infarction was present. Twelve patients were in hemodynamic stable condition after arriving in the operating-room. Five patients were hemodynamic unstable, 4 of them were in cardiogenic shock. Four patients died representing an operative mortality rate of 23%. Three patients died from pump failure despite intraaortic balloon counterpulsation in 2 cases. One patient died from cerebral damage 12 day after surgery. All patients who died were in cardiogenic shock preoperatively. Two patients who survived suffered an extensive myocardial infarction. Thus including the patients who died from pump failure the perioperative infarction rate was 30%. From these results it is concluded that emergency ACVB after failed PTCA of the culprit-vessel in patients with unstable angina results in a significant higher mortality and morbidity as compared with patients who had primary surgery for unstable angina. The prognosis of patients after failed PTCA for unstable angina depends on the hemodynamic situation thereafter and becomes worse in patients with cardiogenic shock.
在1985年1月至1988年12月的4年期间,140例患者因不稳定型心绞痛对罪犯血管进行了经皮腔内冠状动脉成形术(PTCA)。17例患者(12%)因血管成形术失败需要急诊主动脉冠状动脉搭桥手术(ACVB)。其中15例患者的罪犯血管为左前降支,2例患者的罪犯血管为优势右冠状动脉。仅2例患者有心肌梗死病史。12例患者进入手术室后血流动力学稳定。5例患者血流动力学不稳定,其中4例处于心源性休克状态。4例患者死亡,手术死亡率为23%。2例患者尽管使用了主动脉内球囊反搏仍死于泵衰竭。1例患者术后12天死于脑损伤。所有死亡患者术前均处于心源性休克状态。2例存活患者发生了大面积心肌梗死。因此,包括死于泵衰竭的患者,围手术期梗死率为30%。从这些结果可以得出结论,与因不稳定型心绞痛接受初次手术的患者相比,不稳定型心绞痛患者罪犯血管PTCA失败后进行急诊ACVB会导致显著更高的死亡率和发病率。不稳定型心绞痛患者PTCA失败后的预后取决于其后的血流动力学情况,心源性休克患者的预后更差。