van Wyk M, Sommers D K, Meyer E C, Moncrieff J
Department of Pharmacology, University of Pretoria, South Africa.
Methods Find Exp Clin Pharmacol. 1990 May;12(4):291-4.
The purpose of this study was to measure gastric emptying by using the cumulative fraction absorbed-time profiles of paracetamol. To evaluate the validity of the method as an index of gastric emptying, six healthy male volunteers were entered into an ethically approved trial using different regimens of cholinergic enhancing (i.e. metoclopramide and neostigmine) and blocking agents (i.e. atropine and pirenzepine) and the results were compared with the bioavailability (i.e. Cmax, Tmax, AUC) parameters of paracetamol as an index of gastric emptying. The cumulative fractional absorption of paracetamol appears to be a valuable index for the measurement of gastric emptying.
本研究的目的是通过对乙酰氨基酚的累积吸收分数-时间曲线来测定胃排空。为评估该方法作为胃排空指标的有效性，六名健康男性志愿者参与了一项经伦理批准的试验，采用不同方案的胆碱能增强剂（即甲氧氯普胺和新斯的明）和阻滞剂（即阿托品和哌仑西平），并将结果与对乙酰氨基酚的生物利用度（即Cmax、Tmax、AUC）参数进行比较，以此作为胃排空的指标。对乙酰氨基酚的累积分数吸收似乎是测量胃排空的一个有价值的指标。
