脂蛋白(a)是沙特人群冠状动脉疾病的存在、弥漫程度及严重程度的一个特征。

Lipoproteina(a) is a feature of the presence, diffuseness, and severity of coronary artery disease in Saudi population.

作者信息

Habib Syed S, Abdel-Gader Abdelgalil M, Kurdi Mohammad I, Al-Aseri Zohair, Soliman Mona M

机构信息

Department of Physiology, College of Medicine, King Khalid University Hospital, Riyadh, King Saud University, Kingdom of Saudi Arabia.

出版信息

Saudi Med J. 2009 Mar;30(3):346-52.

PMID:19271061

Abstract

OBJECTIVES

To study lipoprotein(a) [Lp(a)] levels in Saudi patients with angiographically defined coronary artery disease and to see its relationship with its severity and diffuseness.

METHODS

This cross sectional study was carried out at King Khalid University Hospital, Riyadh, Saudi Arabia in 2006-2007. One hundred and forty-seven individuals with coronary artery disease (CAD) and 49 healthy individuals matched for age and body mass index were studied. Among CAD patients, 133 underwent angiography. Blood samples were analyzed for total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) and Lp(a).

RESULTS

Coronary artery disease patients had higher Lp(a) levels than controls (25.78 +/- 25.09 mg/dl versus 14.57 +/- 11.81 mg/dl, p=0.0030). Patients without stenosis (10.97 +/- 8.06 mg/dl) and one vessel involvement (19.67 +/- 17.33 mg/dl) had significantly lower levels of Lp(a) compared to double (31.88 +/- 32.17 mg/dl) and triple (29.70 +/- 28.12 mg/dl) vessel disease. Lipoprotein(a) levels correlated significantly with coronary vessel score (r=0.234, p=0.033) and Gensini score (r=0.256, p=0.02). Smoking (odds ratio [OR]: 1.86; 95% confidence interval [CI]: 1.020-2.510; p=0.04), TG levels (OR: 2.04; 95% CI: 1.251-4.932; p=0.03) and Lp(a) levels (OR: 1.56; 95% CI: 1.033-3.687; p=0.025) significantly predicted CAD severity. High risk levels of Lp(a) >/= 30 mg/dL were present in 66.7% of CAD patients.

CONCLUSION

Lipoprotein(a) levels are significantly higher in Saudi patients with CAD compared to healthy individuals, and are associated with more severe and diffuse blockage of the coronary vessels.

摘要

目的

研究经血管造影确诊的沙特冠状动脉疾病患者的脂蛋白(a)[Lp(a)]水平，并观察其与疾病严重程度及病变范围的关系。

方法

这项横断面研究于2006 - 2007年在沙特阿拉伯利雅得的哈立德国王大学医院开展。研究对象包括147例冠状动脉疾病（CAD）患者以及49例年龄和体重指数相匹配的健康个体。在CAD患者中，133例接受了血管造影检查。对血液样本进行总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）和Lp(a)分析。

结果

冠状动脉疾病患者的Lp(a)水平高于对照组（25.78±25.09mg/dl对14.57±11.81mg/dl，p = 0.0030）。与双支血管病变（31.88±32.17mg/dl）和三支血管病变（29.70±28.12mg/dl）的患者相比，无狭窄（10.97±8.06mg/dl）和单支血管受累（19.67±17.33mg/dl）的患者Lp(a)水平显著更低。脂蛋白(a)水平与冠状动脉血管评分（r = 0.234，p = 0.033）和Gensini评分（r = 0.256，p = 0.02）显著相关。吸烟（比值比[OR]：1.86；95%置信区间[CI]：1.020 - 2.510；p = 0.04）、TG水平（OR：2.04；95%CI：1.251 - 4.932；p = 0.03）和Lp(a)水平（OR：1.56；95%CI：1.033 - 3.687；p = 0.025）显著预测CAD严重程度。66.7%的CAD患者Lp(a)水平≥30mg/dL，处于高危水平。