Gupta R, Vasisht S, Bahl V K, Wasir H S
Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.
Int J Cardiol. 1996 Dec 13;57(3):265-70. doi: 10.1016/s0167-5273(96)02800-8.
Lipoprotein (a) [Lp(a)] levels have been correlated with angiographically defined coronary artery disease (CAD). Pattern of Lp(a) distribution in various racial groups is different. To study this relationship in Indian patients, plasma levels of Lp(a) and other lipid values were assessed in 101 patients undergoing coronary arteriography. Lp(a) concentration was higher in CAD group (n = 77) compared to normal coronary artery group (n = 24) (26.83 +/- 22.09 mg/dl vs. 15.07 +/- 14.61 mg/dl, P < 0.05). Lp(a) values had graded association with CAD. In Lp(a) quartile of < 5 mg/dl, 66.7% patients had CAD; in Lp(a) quartile of 5-25 mg/dl, 69.0% had CAD; Lp(a) quartile of 26-75 mg/dl, 87.5% had CAD; and in Lp(a) quartile of > or = 76 mg/dl, all patients had CAD. High density lipoprotein (HDL) cholesterol was higher in the normal coronary artery group as compared to CAD group (45.25 +/- 8.26 mg/dl vs. 41.83 +/- 16.47 mg/dl; NS). In HDL quartile of < 35 mg/l, 88.9% patients had angiographically defined CAD. Plasma values of total cholesterol, triglycerides (TG), apolipoprotein-A1 (Apo-A1), apolipoprotein-B (Apo-B), low density lipoprotein (LDL) cholesterol, LDL/HDL cholesterol ratio and Apo A1/B ratio were not significantly different in the groups with normal coronary arteries and CAD. Our results indicate that the measurement of Lp(a) provides a better marker for predicting the presence of angiographically defined CAD as compared to traditional measures.
脂蛋白(a)[Lp(a)]水平与血管造影确定的冠状动脉疾病(CAD)相关。Lp(a)在不同种族群体中的分布模式有所不同。为了研究印度患者中的这种关系，对101例接受冠状动脉造影的患者进行了Lp(a)血浆水平及其他血脂值的评估。与正常冠状动脉组(n = 24)相比，CAD组(n = 77)的Lp(a)浓度更高(26.83±22.09mg/dl对15.07±14.61mg/dl，P<0.05)。Lp(a)值与CAD呈分级关联。在Lp(a)四分位数<5mg/dl的患者中，66.7%患有CAD；在Lp(a)四分位数为5 - 25mg/dl的患者中，69.0%患有CAD；在Lp(a)四分位数为26 - 75mg/dl的患者中，87.5%患有CAD；而在Lp(a)四分位数≥76mg/dl的患者中，所有患者均患有CAD。与CAD组相比，正常冠状动脉组的高密度脂蛋白(HDL)胆固醇更高(45.25±8.26mg/dl对41.83±16.47mg/dl；无显著性差异)。在HDL四分位数<35mg/l的患者中，88.9%经血管造影确诊患有CAD。正常冠状动脉组和CAD组的总胆固醇、甘油三酯(TG)、载脂蛋白A1(Apo - A1)、载脂蛋白B(Apo - B)、低密度脂蛋白(LDL)胆固醇、LDL/HDL胆固醇比值及Apo A1/B比值的血浆值无显著差异。我们的结果表明，与传统检测方法相比，Lp(a)检测为预测血管造影确定的CAD的存在提供了更好的标志物。
