Jost W H, Raulf F, Müller-Lobeck H
Department of Neurology, University of Saarland, Homburg/Saar, Germany.
Acta Neurol Scand. 1991 Jul;84(1):73-4. doi: 10.1111/j.1600-0404.1991.tb04908.x.
The current report describes 15 patients, 14 women and one man, in whom anorectal ulceration appeared after use of ergotamine suppositories. In seven cases there was only ulceration to be seen, whereas in eight anovaginal or rectovaginal fistulae were visible. Symptoms are not specific. In the majority of situations, ulceration can usually be treated successfully by immediate withdrawal alone. In one case a stenosis of the anal canal remained. Fistulae need surgical intervention. Two fistulae could be treated sufficiently by the local flap technique. In six cases a colostomy was needed, which was transient in five and permanent in one patient. One recurrence was seen after continued ergot-abuse. Dosage is not in direct correlation to ulceration.
本报告描述了15例患者，其中14名女性和1名男性，在使用麦角胺栓剂后出现了肛肠溃疡。7例仅可见溃疡，而8例可见肛门阴道或直肠阴道瘘。症状不具有特异性。在大多数情况下，通常仅通过立即停药就能成功治疗溃疡。有1例出现肛管狭窄。瘘管需要手术干预。2例瘘管可通过局部皮瓣技术得到充分治疗。6例需要进行结肠造口术，其中5例为暂时性，1例为永久性。持续滥用麦角后出现1例复发。剂量与溃疡并无直接关联。
