Jay V, Kovacs K, Horvath E, Lloyd R V, Smyth H S
Department of Pathology, Princess Margaret Hospital, Toronto, Ontario, Canada.
Acta Neuropathol. 1991;82(2):147-51. doi: 10.1007/BF00293958.
Prolactin cell adenoma is the most frequently found lesion in surgically removed pituitaries of patients with hyperprolactinemia. However, in several instances, instead of prolactin cell adenoma, other lesions are encountered by morphological investigation. We report here the morphological findings in a patient with hyperprolactinemia who underwent transsphenoidal pituitary surgery for suspected prolactin cell adenoma. A morphological diagnosis of tumor could not be confirmed and massive diffuse prolactin cell hyperplasia was identified. The aim of this publication is to describe the lesion by histology, immunocytochemistry, electron microscopy, and in situ hybridization and to call attention to primary prolactin cell hyperplasia which can mimic prolactin cell adenoma.
催乳素细胞腺瘤是高催乳素血症患者经手术切除的垂体中最常见的病变。然而，在一些情况下，经形态学检查发现的并非催乳素细胞腺瘤，而是其他病变。我们在此报告一名高催乳素血症患者的形态学检查结果，该患者因疑似催乳素细胞腺瘤接受了经蝶窦垂体手术。肿瘤的形态学诊断未能得到证实，而是发现了大量弥漫性催乳素细胞增生。本出版物的目的是通过组织学、免疫细胞化学、电子显微镜和原位杂交来描述该病变，并提醒注意可模仿催乳素细胞腺瘤的原发性催乳素细胞增生。
