Groff T R, Shulkin B L, Utiger R D, Talbert L M
Obstet Gynecol. 1984 Mar;63(3 Suppl):86S-89S.
Two women who presented with amenorrhea-galactorrhea and hyperprolactinemia associated with x-ray evidence of pituitary enlargement and suprasellar extension were found to have primary hypothyroidism. Resolution of the pituitary enlargement and galactorrhea occurred after thyroid hormone replacement. Both women spontaneously ovulated and conceived, and normal pregnancies resulted. Amenorrhea, galactorrhea, and/or pituitary enlargement may be the principal manifestations of primary hypothyroidism. In such patients, it is imperative that primary hypothyroidism be excluded before drug or surgical therapy for presumed prolactinoma is undertaken. When these findings are due to primary hypothyroidism, thyroid hormone replacement alone is adequate therapy.
两名出现闭经-溢乳和高催乳素血症且伴有垂体增大及鞍上扩展的X线证据的女性被发现患有原发性甲状腺功能减退症。甲状腺激素替代治疗后垂体增大和溢乳症状得到缓解。两名女性均自发排卵并受孕，且妊娠正常。闭经、溢乳和/或垂体增大可能是原发性甲状腺功能减退症的主要表现。对于此类患者，在对疑似催乳素瘤进行药物或手术治疗之前，必须排除原发性甲状腺功能减退症。当这些表现是由原发性甲状腺功能减退症引起时，仅甲状腺激素替代治疗就是足够的疗法。
