从一名胆管炎患者分离出的维罗纳气单胞菌温和生物变种临床分离株中碳青霉烯类耐药性的产生。

Development of imipenem resistance in an Aeromonas veronii biovar sobria clinical isolate recovered from a patient with cholangitis.

作者信息

Sánchez-Céspedes Javier, Figueras Maria José, Aspiroz Carmen, Aldea Maria José, Toledo Miguel, Alperí Anabel, Marco Francesc, Vila Jordi

机构信息

Servei de Microbiologia, Centre de Diagnòstic Biomèdic, Hospital Clínic, IDIBAPS, Facultat de Medicina, Universitat de Barcelona, Villarroel 170, 08036 Barcelona, Spain.

Unitat de Microbiologia, Departament de Ciències Mèdiques Bàsiques, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Sant Llorenç 21, 43201 Reus, Spain.

出版信息

J Med Microbiol. 2009 Apr;58(Pt 4):451-455. doi: 10.1099/jmm.0.47804-0.

DOI:10.1099/jmm.0.47804-0

PMID:19273640

Abstract

Several imipenem-susceptible and -resistant Aeromonas veronii biovar sobria isolates with different morphologies and antimicrobial susceptibilities recovered from bile samples of a patient with cholangitis were analysed. These isolates belonged to the same clone and the imipenem-resistant strains showed overexpression of the imiS gene, encoding a chromosomal carbapenemase. These results should make clinicians aware of the possible emergence of multidrug-resistant A. veronii biovar sobria, perhaps as a consequence of previous treatment of a urinary tract infection with amoxicillin plus clavulanic acid.

摘要

对从一名胆管炎患者胆汁样本中分离出的几株形态和药敏性不同的对亚胺培南敏感和耐药的维罗纳气单胞菌温和生物变种菌株进行了分析。这些分离株属于同一克隆，耐亚胺培南菌株显示编码染色体碳青霉烯酶的imiS基因过表达。这些结果应使临床医生意识到多重耐药维罗纳气单胞菌温和生物变种可能出现，这可能是先前用阿莫西林加克拉维酸治疗尿路感染的结果。