Makino S, Ikemori K, Kashima T, Fukuda T
J Allergy Clin Immunol. 1977 May;59(5):348-52. doi: 10.1016/0091-6749(77)90016-1.
Reduced response of beta adrenergic receptors, especially beta-2 receptors, has been suggested as a contributing factor in the etiology of asthma. Cyclic adenosine monophosphate (AMP) production in lymphocytes after exposure to 10(-3) M salbutamol, predominantly a beta-2 receptor stimulant, was significantly less in asthmatic subjects than in normal subjects, while there was no significant difference in cyclic AMP response to 10(-3) M norepinephrine, predominantly a beta-1 receptor stimulant. Both drugs evoked the maximum response at 10(-3) M. The cyclic AMP response to salbutamol of 5 asthmatic subjects being treated with steroids was diminished significantly compared with that of 7 patients not treated with steroids; however, the response to norepinephrine was similar in both groups. The degree of the abnormality in the beta-2 receptor response seems to be related to the severity of the asthma.
β-肾上腺素能受体，尤其是β2受体反应性降低，被认为是哮喘病因中的一个促成因素。在接触主要为β2受体激动剂的10(-3)M沙丁胺醇后，哮喘患者淋巴细胞中环磷酸腺苷（AMP）的生成明显少于正常受试者，而对主要为β1受体激动剂的10(-3)M去甲肾上腺素的环磷酸腺苷反应则无显著差异。两种药物在10(-3)M时均引发最大反应。与7例未接受类固醇治疗的患者相比，5例接受类固醇治疗的哮喘患者对沙丁胺醇的环磷酸腺苷反应明显减弱；然而，两组对去甲肾上腺素的反应相似。β2受体反应异常的程度似乎与哮喘的严重程度有关。
