Passowicz-Muszyńska E
Katedry i Kliniki Chorób Wewnetrznych AM we Wrocławiu.
Pol Tyg Lek. 1990;45(29-31):608-11.
The study involved 30 subjects: 15 healthy individuals and 15 patients with atopic bronchial asthma of the moderate degree. Salbutamol was administered to asthmatic patients in the intravenous infusion for 7 days. beta-adrenergic receptor density in the lymphocytes and FEV1 were evaluated before and after therapy. Moreover, isoprenaline test was carried out to evaluate the sensitivity of the bronchial smooth muscle to beta-agonist. The test was performed prior to and after salbutamol therapy. It was found that beta-receptor agonist statistically significantly decreases beta-adrenergic receptor density. Equivalently, bronchial smooth muscle is less sensitive to beta-agonist in the same degree as a decrease in beta-adrenergic receptor density in the peripheral blood lymphocytes.
该研究涉及30名受试者：15名健康个体和15名中度特应性支气管哮喘患者。对哮喘患者静脉输注沙丁胺醇7天。在治疗前后评估淋巴细胞中的β-肾上腺素能受体密度和第一秒用力呼气量（FEV1）。此外，进行异丙肾上腺素试验以评估支气管平滑肌对β-激动剂的敏感性。该试验在沙丁胺醇治疗前后进行。结果发现，β-受体激动剂在统计学上显著降低β-肾上腺素能受体密度。同样，支气管平滑肌对β-激动剂的敏感性降低程度与外周血淋巴细胞中β-肾上腺素能受体密度的降低程度相同。
