Audet Maxime, Panaro Fabrizio, Piardi Tullio, Huang Ping, Cag Murat, Cinqualbre Jacques, Wolf Philippe
Centre de Chirurgie Viscérale et de Transplantation, Hôpital de Hautepierre, Hopitaux Universitaires de Strasbourg-Université Louis Pasteur, Strasbourg, France.
Clin Dev Immunol. 2008;2008:715769. doi: 10.1155/2008/715769. Epub 2009 Mar 5.
The authors reviewed the passenger lymphocyte syndrome (PLS) that has appeared after transplantation. The definition, mechanism, serological, clinical features, and treatment for PLS after solid organ transplantation, especially liver transplantation, are described. The PLS refers to the clinical phenomenon of alloimmune hemolysis resulting from the adoptive transfer of viable lymphocytes from donor during solid organ or hematopoietic stem cell transplant. Sometimes, it is very severe and may cause "unexplained" hemolysis during the postoperative period. The authors reviewed literature about the PLS in liver transplantation.
作者回顾了移植后出现的过客淋巴细胞综合征（PLS）。描述了实体器官移植尤其是肝移植后PLS的定义、机制、血清学、临床特征及治疗。PLS指在实体器官或造血干细胞移植期间，供体活淋巴细胞的过继转移导致的同种免疫性溶血的临床现象。有时，其非常严重，可在术后引起“不明原因”的溶血。作者回顾了关于肝移植中PLS的文献。
