Adachi M, Ohya T, Hirata Y, Yumita A, Yamashita H, Shirato S
Department of Ophthalmology, University of Tokyo, School of Medicine, Bunkyo-ku, Japan.
Nippon Ganka Gakkai Zasshi. 1991 Jul;95(7):657-62.
A full-thickness sclerostomy from the anterior chamber to the subconjunctival space was created in 9 eyes of 7 rhesus monkeys using an argon endolaser. After the injection of sodium hyaluronate into the subconjunctival space and the anterior chamber, a 300 microns fiberoptic fiber coupled with an argon laser (HGM, model 20) was inserted to the anterior chamber and positioned at the trabecular meshwork. A patent sclerostomy was created in all 9 eyes by 1 to 3 laser pulses with an energy of 4W with a duration of 0.5 second. Preoperative intraocular pressure in treated eyes and untreated eyes, measured with a pneumatic tonometer, was the same. After one month, the intraocular pressure of the treated eyes was 4.6 +/- 0.4mmHg lower than that of the untreated eyes. Histologic study revealed that the sclerostomies with a diameter of 200-300 microns from the anterior chamber opening to the subconjunctival space were patent at one month after the treatment. Internal sclerostomy with a high powered argon endolaser may hold potential as a new filtering procedure which can easily be performed with a minimum of conjunctival damage.
使用氩离子眼科激光仪，在7只恒河猴的9只眼中从前房至结膜下间隙制作全层巩膜造瘘口。在向结膜下间隙和前房注射透明质酸钠后，将一根与氩离子激光（HGM，20型）耦合的300微米光纤插入前房并置于小梁网处。通过1至3次能量为4W、持续时间为0.5秒的激光脉冲，在所有9只眼中均成功制作了通畅的巩膜造瘘口。使用气动眼压计测量，治疗眼和未治疗眼的术前眼压相同。一个月后，治疗眼的眼压比未治疗眼低4.6±0.4mmHg。组织学研究显示，治疗后一个月，从前房开口至结膜下间隙直径为200 - 300微米的巩膜造瘘口通畅。高能量氩离子眼科激光进行的内巩膜造瘘术可能具有作为一种新的滤过手术的潜力，该手术可以在对结膜损伤最小的情况下轻松完成。
