Hara T, Yamamoto T, Adachi M, Shirato S
Department of Ophthalmology, University of Tokyo School of Medicine, Bunkyo-ku, Japan.
Nippon Ganka Gakkai Zasshi. 1993 Jul;97(7):786-91.
THC-YAG laser sclerostomy was performed in 7 eyes of 6 monkeys. The 26-gauge optic probe, which delivers energy perpendicularly to the long axis of the probe, was inserted through a 1-mm conjunctival stab incision, 6-7 mm away from the limbus, and the probe tip was positioned at the sclerostomy site. Pulse energy of 80 mJ or 100 mJ was used with a repetition rate of 5 pulses per second. Total energy levels to produce a new outflow pathway ranged from 1.2 to 6.6 J (2.8 +/- 1.2 J). After the surgery, 5-fluorouracil (0.1 mg daily) was injected subconjunctivally for 7 days, and intraocular pressure measurements and ophthalmic examination were performed for 4 weeks. Eyes were enucleated just after surgery or 1 week or 4 weeks after surgery. Intraocular pressures in operated eyes at 1 week and 4 weeks after surgery were reduced to 7-10 (9 +/- 1.2) mmHg, and 0-11 (3.5 +/- 4.3) mmHg, respectively, in comparison with intraocular pressures in nonoperated eyes. Histological examination revealed that the sclerostomy hole with a diameter of 150 microns just after surgery had narrowed at 1 week, and was closed by subconjunctival proliferative tissues at 4 weeks after surgery.
对6只猴子的7只眼进行了钕钇铝石榴石激光巩膜造瘘术。通过一个距角膜缘6 - 7毫米的1毫米结膜穿刺切口插入26号光学探头，该探头垂直于探头长轴传递能量，探头尖端置于巩膜造瘘部位。使用80毫焦或100毫焦的脉冲能量，重复频率为每秒5个脉冲。产生新的房水流出通道的总能量水平在1.2至6.6焦耳之间（2.8±1.2焦耳）。术后，结膜下注射5 - 氟尿嘧啶（每日0.1毫克），持续7天，并进行4周的眼压测量和眼科检查。术后即刻、术后1周或4周摘除眼球。与未手术眼的眼压相比，手术眼术后1周和4周的眼压分别降至7 - 10（9±1.2）毫米汞柱和0 - 11（3.5±4.3）毫米汞柱。组织学检查显示，术后即刻直径为150微米的巩膜造瘘孔在1周时变窄，术后4周被结膜下增殖组织封闭。
