Department of Obstetrics and Gynaecology, Yuzuncu Yil University, Kadin Hastaliklari ve Dogum Anabilim Dali, Van, Turkey.
Arch Gynecol Obstet. 2009 Dec;280(6):889-92. doi: 10.1007/s00404-009-1005-4. Epub 2009 Mar 11.
To investigate the association of neonatal bilirubin levels with oxytocin and misoprostol use for labour induction.
A total of 100 neonates were included in the study. The first group consisted of 50 healthy babies of women who had received oxytocin infusion, and the second group consisted of 50 healthy babies of women who had received 25 microg misoprostol every 4 h placed in the posterior fornix for labour induction. Bilirubin and haematocrit levels were measured in all on days 1 and 4 of the neonatal period.
The levels of bilirubin in the oxytocin group were significantly higher than those in the misoprostol group on day 1 [4.42 +/- 0.27 vs. 3.55 +/- 0.28 mg/dl (P = 0.035)] while they were higher also on day 4 but not significantly so [7.47 +/- 0.63 vs. 6.86 +/- 0.65 mg/dl (P = 0.525)]. The mean haematocrit levels on day 1 were 50.62 +/- 1.23 and 58.04 +/- 1.30 in groups 1 and 2, respectively, with a significant difference between them. The levels were 52.31 +/- 1.27 and 58.96 +/- 1.14 on day 4 and the difference was again significant. P < 0.05 indicated statistical significance.
Labour induction with misoprostol and oxytocin does not seem to have harmful effects on bilirubin levels in the neonate.
探讨新生儿胆红素水平与催产素和米索前列醇用于引产的关系。
本研究共纳入 100 例新生儿。第一组包括 50 例接受催产素输注的健康婴儿，第二组包括 50 例接受 25μg米索前列醇每 4 小时置于后穹窿引产的健康婴儿。在新生儿期的第 1 天和第 4 天测量所有婴儿的胆红素和红细胞压积水平。
催产素组新生儿胆红素水平在第 1 天显著高于米索前列醇组[4.42 +/- 0.27 vs. 3.55 +/- 0.28 mg/dl (P = 0.035)]，第 4 天也升高，但差异无统计学意义[7.47 +/- 0.63 vs. 6.86 +/- 0.65 mg/dl (P = 0.525)]。第 1 天的平均红细胞压积水平分别为 50.62 +/- 1.23 和 58.04 +/- 1.30，两组间差异有统计学意义。第 4 天的水平分别为 52.31 +/- 1.27 和 58.96 +/- 1.14，差异再次有统计学意义。P<0.05 表示有统计学意义。
米索前列醇和催产素引产似乎不会对新生儿胆红素水平产生有害影响。
